Helicobacter pylori density and expression of gastric mucosal interleukin-8 in dyspeptic patients

Hesti Ismarini and Iswan Abbas Nusi and Ummi Maimunah and Poernomo Boedi Setiawan and Herry Purbayu and Titong Sugihartono and Ulfa Kholili and Budi Widodo and Husin Thamrin and Muhammad Miftahussurur and Amie Vidyani (2019) Helicobacter pylori density and expression of gastric mucosal interleukin-8 in dyspeptic patients. New Armenian Medical Journal, 13 (1). pp. 40-47. ISSN 18290825

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Abstract

Background: The density of the H. pylori colonies is associated with more severe clinical manifestations, chronic infections, ineffective therapy responses and malignant events. Interleukin-8 (IL-8) is one of cytokines that plays a role in the inflammatory process that results in gastric mucosal damage. We determined the association between H. pylori density and gastric mucosal IL-8 expression in dyspeptic patients. Methods: H. pylori density was determined using histopathology based on Updated Sydney System. IL-8 levels were measured using immunohistochemistry from the gastric biopsy. Results: There was significant difference between gastric mucosal IL-8 expression obtained in gastric mucosal gland epithelium (p = 0.028) at mild and high density of H. pylori (p = 0.013). There was a correlation between H. pylori density with gastric mucosal IL-8 expression of glandular epithelium (r = 0.622; p = 0.004), surface epithelium (r = 0.510; p = 0.026), and inflammatory cells (r = 0.054; = 0.028). Conclusion: We found a significant positive correlation between H. pylori density and gastric mucosal IL-8 expression in dyspeptic patients. © 2019, Yerevan State Medical University. All rights reserved.

Item Type: Article
Uncontrolled Keywords: antibiotic agent; CagA protein; interleukin 8; lipopolysaccharide; outer membrane protein; proton pump inhibitor; virulence factor, adult; Article; bacterial colonization; bacterium adherence; bloating; cell density; cell infiltration; clinical article; cross-sectional study; dyspepsia; education; endoscopy; epigastric pain; epithelium; female; gastritis; gastrointestinal motility; heartburn; Helicobacter infection; histopathology; human; human tissue; immunohistochemistry; infection risk; inflammation; inflammatory cell; lamina propria; male; nausea; observational study; protein expression; stomach biopsy; stomach mucosa; vomiting
Subjects: R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions: Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:
CreatorsNIM
Hesti IsmariniUNSPECIFIED
Iswan Abbas NusiNIDN0028025003
Ummi MaimunahNIDN8896900016
Poernomo Boedi SetiawanNIDN8886900016
Herry PurbayuNIDN8884800016
Titong SugihartonoNIDN8836800016
Ulfa KholiliNIDN0004047511
Budi WidodoNIDN8804800016
Husin ThamrinNIDN8825800016
Muhammad MiftahussururNIDN0029097909
Amie VidyaniNIDN0028018002
Depositing User: PPJPI
Date Deposited: 06 Mar 2020 00:54
Last Modified: 06 Mar 2020 00:54
URI: http://repository.unair.ac.id/id/eprint/94587
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