Ni Made Linawati and I Gusti Ngurah Mayun and I Gusti Nyoman Sri Wiryawan and Nyoman Sri Budayanti and Ni Made Mertaniasih and Fedik Abdul Rantam and I Nyoman Wande and I Gusti Ayu Dewi Ratnayanti and Ida Ayu Ika Wahyuniari and I Wayan Sugiritama and I Gusti Kamasan Arijana (2013) Perbedaan Gambaran Histopatologi Granuloma Paru Mencit Setelah Diinfeksi Mycobacterium tuberculosis dan atau Intervensi Silika. Jurnal Veteriner, 14 (1). pp. 53-60. ISSN 1411-8327

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Abstract

The characteristics of lung tuberculosis is granuloma, which is consisted of lymphocytes andmacrophages that show the interaction between immune cells and M.tb. Granuloma is the organizationprocess which is depend on lymphocytes invasion, adhesion molecules and chemokine fasilitation. Silicosiswhich is caused by silica, can influence granuloma in the lung. The features of granuloma is variationdepend on the elicited agent and immune reaction. The main purpose of this study was to prove thehistopathology differences of mice lung granuloma caused by M.tb infection, silica intervention and bothin 3th and 7th weeks. It was 45 mice Balb-c strain, divided into 3 groups; P1 got M.tb infection with H37Rvstrain 105 perml,P2 got silica intervention with 60 micro litre and, P3 got both of M.tb infection and silica intervention. Termination of each group were held on 3 and 7 weeks of intervention, continued byhistopathology examination. In the histopathology feature, we done semi-quantitative prosedure to measurelung damage by using Dormans scores; perivasculitis, peribronchiolitis, alveolitis and granuloma. Oneway anova to analysis the differences of histopathologycal result among these groups (P< 0,05). Resultshowed the significant differences among these group. In the 3th weeks, we found mild lung damage werehappened in all groups with granuloma, without necrosic (P1 and P2). In the 7th weeks we found severe lungdamage in P3 with necrotic and fibrotic granuloma sign, with necrosis in P1, with fibrotic in P2. Weconcluded the worst lung damage happened in 7th weeks in group which are got M.tb infection and silicaintervention, with granuloma characterictic of necrosic and fibrotic.

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