Addition of Anti-Toxoplasma gondii Membrane Immunoglobulin Y to Reduce Necrotic Index in Mice Liver

Heni Puspitasari and Lucia Tri Suwanti and Mufasirin (2018) Addition of Anti-Toxoplasma gondii Membrane Immunoglobulin Y to Reduce Necrotic Index in Mice Liver. African Journal of Infectious Diseases, 12. pp. 72-75. ISSN 2006-0165

[img] Text (Journal)
Bukti C 03 Addition of Anti-Toxoplasma .....pdf

Download (2MB)
[img] Text (Peer Review)
Peer review C 03.pdf

Download (2MB)
[img] Text (Turn It In)
Turnitin Bukti C 03 ADDITION OF ANTI- Toxoplasma gondii ....pdf

Download (924kB)
Official URL: https://journals.athmsi.org/index.php/AJID/article...

Abstract

Background The study aimes to determine the effect of administering anti-T. gondii membrane IgY against liver damage (Necrotic index) and the effectiveness of the antibody’s delivery time. Materials and Methods This research was a laboratory experiment with five treatments and five replicantions. Each treatment used female mice (Mus musculus) as animal models. The treatment groups consisted of a P0 group (not infected), P1 group (infected), P2 group (anti- T. gondii membrane IgY given one day before infection), P3 group (anti-T. gondii membrane IgY given together with infection) and P4 group (anti-T. gondii membrane IgY given two days after the infection. A dose of anti- T. gondii membrane IgY as many as 75 ug/head and infectious dose of 10 tachyzoites/head were given. Four days after infection mice were sacrified and examined. Finally, necrotic index in histopathological liver using Hematoxylin Eosin. Results The percentage of necrotic index liver showed that result treatment of P2 and P3 treatment that lower than another treatment. Conclusion Thus, it can be concluded that administration of anti-T. gondii membrane IgY can reduce liver cell necrotic index and it was greatest when given before and simultaneously with infection. Key words: Toxoplasma gondii, immunoglobulin Y, liver damage

Item Type: Article
Uncontrolled Keywords: Toxoplasma gondii, immunoglobulin Y, liver damage
Subjects: S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF811-909 Veterinary medicine of special organs, regions, and systems
Divisions: 06. Fakultas Kedokteran Hewan > Parasitologi Veteriner
Creators:
CreatorsNIM
Heni PuspitasariUNSPECIFIED
Lucia Tri SuwantiNIDN0028086208
MufasirinNIDN0011076705
Depositing User: Nn Erna Dwi Indriyani
Date Deposited: 20 Apr 2020 02:31
Last Modified: 20 Apr 2020 02:31
URI: http://repository.unair.ac.id/id/eprint/95098
Sosial Share:

Actions (login required)

View Item View Item