PERBANDINGAN DAYA ANTIBAKTERI BAKTERIOSIN DALAM SEDIAAN OBAT PROBIOTIK

DEO GRATIA E. MARIA L. LEDJO, 050610210 (2011) PERBANDINGAN DAYA ANTIBAKTERI BAKTERIOSIN DALAM SEDIAAN OBAT PROBIOTIK. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Probiotic drug is a drug that contain probiotic bacteria. Probiotics is life microbial feed supplement; which beneficially affect the host animal by improving its intestinal microbial balance. The probiotic bacteria produce antimicrobial substance; that can inihibit the growth of pathogenic bacteria, that called bacteriocin. One of bacteriocin is nisin, which exhibit antimicrobial activity against a wide range of Gram positive bacteria, and is particularly affective against bacterial spores. Three sample of probiotic drug contained in the marketplace, have been extracted to precipitate the bacteriocin. The extracts were then analyzed by using TLC-bioautography methods with n-butanol, acetate acid and water as mobile phase and Staphylococcus aureus ATCC 25923 as pathogenic bacteria. Of inhibition zone diameter obtained, can be known whether in the the same concentration, sample of probiotic drug have different antibacterial activity. There are different profile biaoutogram from extraxted samples of probiotic drug. None of that extracted samples have the same rf with nisin. All of etracted sample have microbial activity but smaller than nisin activity against Staphylococcus aureus ATCC 25923 bacteria.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF 268 / 11 Led p
Uncontrolled Keywords: ANTIBACTERIAL AGENT
Subjects: R Medicine
R Medicine > RC Internal medicine
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
DEO GRATIA E. MARIA L. LEDJO, 050610210UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorNOOR ERMA, Dr. S.Apt. MSUNSPECIFIED
ContributorISNAENI, Dr. Hj. Apt., MSUNSPECIFIED
Depositing User: Nn Deby Felnia
Date Deposited: 20 Jan 2012 12:00
Last Modified: 05 Jul 2017 20:42
URI: http://repository.unair.ac.id/id/eprint/9522
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