Differentiation Tγδ Lymphocyte cells expressing Interleukin-17 Percentage On Healthy Person and Adult Acute Myeloid Leukemia Patient

Elvan Dwi Widyadi and Yetti Hernaningsih and Endang Retnowati and Ugroseno and Ryzky Widi Atmaja (2017) Differentiation Tγδ Lymphocyte cells expressing Interleukin-17 Percentage On Healthy Person and Adult Acute Myeloid Leukemia Patient. Indonesian Journal of Clinical Pathology and Medical Laboratory, 25 (2). pp. 228-232. ISSN 0854-4263

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Official URL: https://indonesianjournalofclinicalpathology.org/i...

Abstract

Acute Mieloid Leukemia (AML) is a hematologic cause of cancer deaths of 1.2% including a relatively rare disease but by the end of the decade there is an increase in the number of new cases. The immune system in AML is caused by gene mutations giving immunosuppressive effects so that the immune system will be inhibited in eliminating leukemia cells. The immune response of tumors is important to determine the prognosis, development of new cancer immunotherapy as well. One of the subset of lymphocytes T is gdT lymphocyte cell with innate nature, but until now no information is required about gdT cell profile in AML patients. gdT cells have properties as antitumors played by Interferon production g (INF g), and the nature of protumor by interleukin 17 (IL-17). The percentage of lymphocyte T (CD3 +) of AML patients and healthy people did not differ (p = 0.528), indicating, not being activated for proliferation. gdT Lymphocyte cells percentage in healthy people by race, genetic and exposure to the surrounding environment such as infection. Percentage of gdT lymphocyte of AML patients and healthy people was not different from (p = 0.694), showed an immune response by gdT cells Unefected to proliferate. The percentage of gdT llimfocytes expressing the interleukin 17 (gdT17 cells)in patients AML and healthy people did not differ significantly (p = 0.436), this indicates inhibited proliferation.

Item Type: Article
Uncontrolled Keywords: Acute Mieloid Leukemia, T lymphocytes, γδT cells, γδT cells, IL-17
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
Divisions: 01. Fakultas Kedokteran > Patologi Klinik
Creators:
CreatorsNIM
Elvan Dwi WidyadiUNSPECIFIED
Yetti HernaningsihNIDN0020127307
Endang RetnowatiNIDN0071608640
UgrosenoUNSPECIFIED
Ryzky Widi AtmajaUNSPECIFIED
Depositing User: hanif kurniawan
Date Deposited: 01 Jun 2020 12:16
Last Modified: 01 Jun 2020 12:16
URI: http://repository.unair.ac.id/id/eprint/95405
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