KARAKTERISASI SOLID LIPID NANOPARTICLES (SLN) - NATRIUM DIKLOFENAK - SETIL ALKOHOL DENGAN BERBAGAI KADAR TWEEN 80 (8%, 10%, 12%)

AMELIA DWI SULISTIOWATI, 050710175 (2011) KARAKTERISASI SOLID LIPID NANOPARTICLES (SLN) - NATRIUM DIKLOFENAK - SETIL ALKOHOL DENGAN BERBAGAI KADAR TWEEN 80 (8%, 10%, 12%). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Diclofenac sodium was known as an eff ective NSAIDs to relieve joint pain. There are some disadvantages in severa l drug administrations (oral, rectal, parenteral) of diclofenac sodium, so th e topically route has been chosen as alternative drug administrations. Recently, solid lipid nanoparticles (SLN) was greatly investigated as a new drug deliver y system. SLN had several benefits as a topical drug carrier. The ai m of this study was to observe the characteristic of SLN-diclofenac sodium-cetyl alcohol which was formulated by different concentration of Tween 80 (8%, 10%, 12%) and determined SLN with best characteristic at certain concentration of Tween 80. SLN was prepared using high shear homogenization method at 25000 rpm for 8 minutes. The result showed SLN with Tween 80 10% had the best characteristic. SLN with Tween 80 10% had higher pe rcent drugs entrapment (mean 91,36%) and smaller size (mean 11,3 nm) than others

Item Type: Thesis (Skripsi)
Additional Information: KKB KK FF 265 11 Sul k
Uncontrolled Keywords: ANALGESICS
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
AMELIA DWI SULISTIOWATI, 050710175UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTutiek Purwanti, Dra. , Apt., M.Si.UNSPECIFIED
ContributorEsti Hendradi, Dra. Hj. , Apt., M.Si., Ph.D.UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 26 Jan 2012 12:00
Last Modified: 16 Jul 2016 05:53
URI: http://repository.unair.ac.id/id/eprint/9554
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