Juni Ekowati and Nuzul Wahyuning Diyah and Achmad Syahrani (2019) Synthesis And Antiplatelet Activities Of Some Derivatives Of p-Coumaric Acid. Chemistry & Chemical Technology, 13 (3). pp. 296-302. ISSN 19964196

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Abstract

The synthesis of new derivatives of p-coumaric acid was carried out through serial reactions, i.e. alkylating, base hydrolysis, catalytic hydrogenation, and Fisher esterification. All reactions except catalytic hydrogenation were conducted by utilizing microwave irradiation from a household microwave oven. The antiplatelet tests using clotting time showed that p-coumaric acid and its derivatives have antiplatelet activity which is related to the lipophilic nature of the compounds and its affinity with the selected target molecule, i.e. COX-1 enzyme (PDB ID 1CQE).

Item Type:	Article
Uncontrolled Keywords:	p-coumaric acid, antiplatelet, COX-1, clotting time, catalytic hydrogenation.
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi
Creators:	Creators NIM Juni Ekowati NIDN0006026703 Nuzul Wahyuning Diyah NIDN0028126608 Achmad Syahrani NIDN0001045405
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	26 Jun 2020 03:38
Last Modified:	05 Nov 2020 12:33
URI:	http://repository.unair.ac.id/id/eprint/95734
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