STANDARISASI DAN PENETAPAN PROFIL EKSTRAK ETANOL 96% PERIKARPIUM MANGGIS (Garcinia mangostana L.)

INTAN KRIS PRASETYANTI, 050710147 (2011) STANDARISASI DAN PENETAPAN PROFIL EKSTRAK ETANOL 96% PERIKARPIUM MANGGIS (Garcinia mangostana L.). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Mangosteen pericarps ( Garcinia mangostana L. ) had been used as traditional medicine. α -mangosteen, that content in Garciniae pericarpium, was known have cytotoxic activity so that extract of mangosteen pericarps ( Garcinia mangostana L. ) potential to developed as standardized herbal drug and phytopharmaca product. Therefore, in this research, general standard parameter and fingerprint of ethanol 96% extract of mangosteen pericarps was determined. Mangosteen pericarps which originated from Trenggalek, East Java, and then washed, cut, dried by oven in 50 o C and grinded into powders. Furthermore, the powders made into extract by maceration in 96% ethanol for 24 hours. Extract obtained to be condensed by evaporated in vacuo until got a viscous extract. Next, the general standard parameter and fingerprint was determined The result of the general standard parameter determination of ethanol 96% extract mangosteen pericarps ( Garcinia mangostana L. ) showed that value of loss on drying was (18,27 ± 0,02)%b/b, water content was (11,44 ± 0,2) %v/b, total ash content was (1,64 ± 0,04) %b/b, acid insoluble ash content was (1,189 ± 0,09), wáter soluble ash content was (1,46 ± 0,05) %b/b, Pb content was 0,201 mg/kg, Hg and As content was undetected, Cd content was 0,038 mg/kg, Cu content was 0,014 mg/kg, water soluble substances content was (14,48 ± 0,45) %b/b, ethanol soluble substances content was (80,46 ± 1,12) %b/b, and α -mangostin content was (21,65 ± 1,30) %b/b. Fingerprint determination of ethanol 96% extract showed that there are only two peaks in TLC-densitometer chromatogram. Obtained spectra from FTIR show that there are another function group in extract if compared with α - mangosteen standard.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK FF 298 11 Pra s
Uncontrolled Keywords: megakaryocytes ; medicinal plants ; cassia ( gennius)
Subjects: R Medicine > R Medicine (General)
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
INTAN KRIS PRASETYANTI, 050710147UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorSukardiman, Prof. Dr. , Apt., MS.UNSPECIFIED
ContributorAbdul Rahman, Drs. , Apt., M.Si.UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 26 Jan 2012 12:00
Last Modified: 19 Jul 2016 10:59
URI: http://repository.unair.ac.id/id/eprint/9576
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