Suzana and Kholis Amalia Nofianti and Melanny Ika Sulistyowati and Juni Ekowati and Marcellino Rudyanto and Hadi Poerwono and Tutuk Budiati (2014) Sintesis Khalkon dan Derivatnya Menurut Reaksi Kondensasi Claisen Schmidt dengan Iradiasi Gelombang Mikro. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 1 (1). pp. 20-27. ISSN 2580-8303

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Abstract

This research has been done synthesis of chalcone and its derivatives by Claisen Schmidt condensation reaction with microwave irradiation on 400 Watt for 9 minutes using an acid catalyst (bentonite/montmorillonite). The reactions produced chalcone (1,3-diphenyl-2-propen-1-on) and 4-methoxychalcone (1-phenyl-3-(4’-methoxy-phenyl)-2-propen-1-on). Percentage of products were obtained respectively 1.72% and 5.21%. The third compound 2’,4’-dihydroxychalcone couldnot be synthesized with microwave irradiation using bentonite/montmorillonite as catalyst on 400 Watt for 9 minutes. The reaction products were purified by column chromatography. Purity tests were carried out by thin layer chromatography (TLC) and the melting point test. The observed melting points were 51 oC and 73 oC for chalcone and 4-methoxychalcone. Identification of compounds were carried out by UVVIS , FT-IR and 1H-NMR spectroscopies.

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