Juni Ekowati and Nur Chaulah and Tutuk Budiati (2014) Sintesis dan uji in silico turunan asam fenilpropanoat sebagai anti platelet. Berkala Ilmiah Kimia Farmasi, 3 (2). pp. 44-50. ISSN 2302-8270

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Abstract

The objectives of this research were to obtain phenylpropanoic acid derivatives and to approve their activity as antiplatelet. Phenylpropanoic acid and the methoxy substituted of phenylpropanoic acids (ortho and para positions) were synthesized through catalytic hydrogenation of the vynilic double bond of phenylpropenoic acid derivatives. The reaction was carried out at room temperature using Raney-Ni in NaOH condition. The structure of synthesis products were identified by FTIR and 1H-NMR spectroscopy. The yield of phenylpropanoic acid, 3-(4-methoxyphenyl)propanoic acid, 3-(2-methoxyphenyl) propanoic acid were 74%, 61%, 44% respectively. Their activity as antiplatelet was confirmed through in silico study into active site of cyclooxygenase-1 (pdb. 1CQE). The all compounds showed no significantly differences ligand-enzyme interaction energy than acetylsalicylic acid. So, our research concluded that compounds can be used as antiplatelet like acetylsalicylic acid through inhibition of cyclooxygenase-1.

Item Type:	Article
Uncontrolled Keywords:	catalytic hydrogenation, phenylpropanoic acid, Raney-Ni, cyclooxygenase-1, antiplatelet
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi
Creators:	Creators NIM Juni Ekowati NIDN0006026703 Nur Chaulah UNSPECIFIED Tutuk Budiati NIDN0026014804
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	29 Jun 2020 07:06
Last Modified:	29 Jun 2020 07:06
URI:	http://repository.unair.ac.id/id/eprint/95780
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