Kholis Amalia Nofianti and Juni Ekowati and Gde Nyoman Astika (2009) Pengaruh Lama Pemanasan pada Sintesis 2-[2-(4-Metoksi-Fenil)-Vinil]-Benzo[1.3]Oxazin-4-On. Majalah Farmasi Airlangga, 7 (2). pp. 22-27. ISSN 0852-1050

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Abstract

The aim of this research is to compare percentage yield of 2-[2-(4-methoxyphenyl)-vinyl]-benzo[1,3]oxazin-4-one which reaction time was 1 hour, 3 hours, and 6 hours, using anthranilic acid and p-methoxycinnamoyl chloride as starting material and benzene as solvent under temprature of ± 80-90ºC. The products were identified using TLC and melting point determination, UV-Vis spectrophotometry, IR spectrophotometry, 1H-NMR spectrometry inform that the product appropriate with structure of 2-[2-(4-methoxyphenyl)-vinyl]-benzo[1,3]oxazin-4-one. The percentage yield of product from the above reaction are 9.20%; 20.19%; and 21.57% yield for 1 hour, 3 hours, and 6 hours, respectively. The statistical analysis inform that there is no significant difference percentage yield between 3 hours and 6 hours reaction time. And there is significant difference percentage yield between 1 hour and two other reaction time

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