AISYAH ANIS, 050710160 (2011) AKTIVITAS ANTI-Mycobacterium tuberculosis CAMPURAN EKSTRAK MENGKUDU, PEGAGAN, SAMBILOTO DAN CAMPURAN SENYAWA SCOPOLETIN, ASIATIC ACID, ANDROGRAPHOLIDE SECARA IN VITRO. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Tuberculosis (TB), caused by Mycobacter ium tuberculosis (MTB) is the most commonly notified disease and the fifth la rgest cause of mortality. According to WHO report, Indonesia has the fifth highest TB prevalen ce. Due to the fact of multidrug resistance, there is an urgent need for more potent antibiotics and other drug. Natural products have been regarded as one of the most successful strategies for creating new medicines. This research purpose is to determine the value of Minimum Inhibitory Concentration (MIC) against Mycobacterium tuberculosis of mixture of ethanolic extracts of Morinda citrifolia Linn , Centella asiatica (L.) Urban , Andrographis paniculata Ness and mixture of scopoletin, asiatic acid, andrographolide. The assay of Mycobacterium tuberculosis activities was done using Agar-well dillution methods to dete rmine the value of Minimum Inhibitory Concentration (MIC). The results showed that mixture of ethanolic extract Morinda citrifolia Linn , Centella asiatica (L.) Urban , Andrographis paniculata Ness were found to be active agains

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