UJI AKTIVITAS ANTIINFLAMASI ASAM p- METOKSISINAMAT (0,34%) SISTEM SOLID LIPID NANOPARTICLES DENGAN BASIS HPC-H

ABHIMATA PARAMANANDANA, 050710048 (2011) UJI AKTIVITAS ANTIINFLAMASI ASAM p- METOKSISINAMAT (0,34%) SISTEM SOLID LIPID NANOPARTICLES DENGAN BASIS HPC-H. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Kencur ( Kaempferia galanga ) was known as an traditiona l herb to relieve pains and aches. p- Methoxycinnamic acid was proposed to have an anti-inflamatory activity. Solid lipid nanoparticles (SLN) was greatly investigated recently as a new drug delivery system. SLN had severa l benefits as a topical drug carrier. The aim of this study was to observe the area under curve (AUC) each formula with different system using the same gel base (HPC-H). Three different system of p- methoxycinnamic acid was made into topical preparation; p- methoxycinnamic acid with propylene glycol (FI), p- methoxycinnamic acid containing cetyl alchohol, tween 80, propylene glycol w ithout been made to solid lipid nanoparticle system (FII), p- methoxycinnamic acid containing the same component thats loaded to solid lipid nanoparticle system (FIII), 1% sodium diclofenac as positive contro l (K+) and base gel HPC-H as the negative control (K-). All the five formulation were screened for their anti-inflamatory activity using carragenan induced paw edema mode ls respectively. In anti-inflamatory activity, FI, FII and FIII has showed signi ficant inhibition of carrageenan induced rat paw edema compared to control gr oup in which only gel base HPC-H was used. The anti-inflamatory activity of FI and FIII were compareable with 1,0% sodium diclofenac gel which was used as standard. The result of the present study further confirm that p- methoxycinnamic acid loaded solid lipid nanoparticles (SLN) has no significant differences with p methoxycinnamic acid in base gel with area unde r curve as the parameter study.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK FF 293 11 Par u
Uncontrolled Keywords: METOKSISINAMAT
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
ABHIMATA PARAMANANDANA, 050710048UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTristiana Erawati, Dra. ,Apt., Msi.UNSPECIFIED
ContributorTutiek Purwanti, Dra. , Apt.,M.Si.UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 26 Jan 2012 12:00
Last Modified: 05 Jul 2017 22:55
URI: http://repository.unair.ac.id/id/eprint/9582
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