DEA ALICIA WULUNG, 050710174 (2011) KARAKTERISASI ORALLY DISINTEGRATINGb TABLET PIROKSIKAM DENGAN KONSENTRASI CMC-Ca 2.5 % DAN 7.5% MENGGUNAKAN PENGIKAT GELATIN 2% DAN BASIS MANITOL (Dibuat Dengan Metode Freeze Drying). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Piroxicam orally disintegrating tablet was prepared by freeze drying method containing piroxicam, mannito l as filler, gelatin as binder, and CMC-Ca as superdisintegrant. Piroxicam orally disintegrating tablet and physical mixture were characterized using differential thermal analysis (D TA), powder X-ray diffractometry (PXRD), and Scanning Electron Microscope. Effect of varying concentrations of CMC-Ca was also studi ed. DTA studies showed that there was a decrease of piroxicam melting point and enthalpy. The lowest melting point and entahlpy of piroxicam was showed by formulation containing CMC-Ca 7.5%. PXRD study demonstrated that there was no significant decrease in degree of crystallinity of piroxicam in orally disintegrating tablet and physical mixture. This results showed that piroxicam transfor med partially to the amorphous state. Surface morphology of piroxicam orally disi ntegrating tablet showed that tablet made by freeze drying was porous, eventhough there was no clearly difference in porosity among all the formulations

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