MEGAN KUMALA, 050911041 (2013) PENGARUH KADAR POLYPLASDONE XL-10 DALAM EKSIPIEN CO-PROCESSED MANITOL - POLYPLASDONE XL-10 - PVP K-30 TERHADAP MUTU FISIK DAN DISOLUSI ORALLY DISINTEGRATING TABLET PARASETAMOL (Dibuat dengan Metode Cetak Langsung). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Orally disintegrating tablet (ODT) is a tablet that can be rapidly disintegrated in saliva less than a minute. The aim of this research was to determine the effect of varying concentrations of Polyplasdone XL-10 in co-processed excipients mannitol - Polyplasdone XL-10 - PVP K-30 on the physical characterictics and dissolution of paracetamol orally disintegrating tablet. Direct compression method was chosen because it was the simplest method and with the appropriate combination of excipients, this method can produced tablets with fast disintegration time and high mechanical strength. However, no single material is likely to exhibit all the ideal characteristics for direct compression method. Therefore, manipulation of excipient functionality by co-processing was used to achieve the ideal excipients for this method. Tablets were evaluated for thickness, hardness, friability, disintegration time, wetting time, and dissolution. The results showed that higher concentration of Polyplasdone XL-10 will significantly increase the hardness, reduce the friability, accelerate the disintegration time and wetting time, and increase ED30 of the tablets. All of the formula showed disintegration time less than 60 seconds and percent dissolved within 30 minutes more than 80%.

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