Asra Al Fauzi (2018) Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells for Stroke: Rationale, Technique and Early Clinical Experience. In: Proceedings of the International Meeting on Regenerative Medicine: IMRM. Scitepress, Surabaya, pp. 59-64. ISBN 978-989-758-334-6

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Abstract

Stroke, one of the most devastating diseases, is a leading cause of death and disability throughout the world and is also associated with emotional and economic problems. The main purpose of this article is to report the technique and clinical outcome of the intraventricular transplantation of bone marrow mesenchymal stem cells (BM-MSCs) in post-hemorrhagic stroke patients. This clinical study was performed with eight patients with supratentorial hemorrhagic stroke, who had undergone 24 weeks of standard treatment of stroke with stable neurological deficits. All of the patients received stem cell transplantation intraventricularly via an Ommaya reservoir using autologous BM-MSCs. Six months and twelve months after stem cell treatment, the clinical outcomes were measured using the National Institute of Health Stroke Scale (NIHSS).The results of this study showed improvement of NIHSS score values before and after the treatment in 5 patients. No adverse effects or complications were dete cted during the 1 year of observation. Intraventricular transplantation of BM-MSCs showed benefits in improving the functional status of post-hemorrhagic stroke patients. The repeated transplantation procedure is easier and safer to perform via a subcutaneously implanted Ommaya reservoir.

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