Misbakhul Munir (2020) Pengaruh Intensitas Latihan Terhadap Kadar BDNF Pada Hipokampus Mencit Yang Diinduksi Fruktosa. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Introduction: several research show that there is negative correlation between obesity and cognitive function. Physical exercise has a lot of benefits, including the increase of cognitive function and memory. The mechanism that underlying the effect of exercise in increasing memory involves Brain-Derived Neurothropic Factor (BNDF), but which intensity causing this effect is still debatable. Objective: to prove the effect of different exercise intensity to BDNF level in mice hippocampus. Methods: forty mice, male, body weight 20-30 grams were divided into five groups. Those were group without fructose induction and exercise, group without exercise only, and three exercise group (low, moderate, and high-intensity). The load for low, moderate, and hight intensitity was 3%, 6%, and 9% of body weight respectively. Before treatment began, mice had been administered by fructose solution via intragastric to increase fat mass. Exercise were given three times a week for 4 weeks. The hippocampus tissue was taken and then examined by ELISA method to determine the BDNF level. Results: BDNF levels in group without fructose induction and exercise obtained a mean 233,63±33,37 pg/ml, in group without exercise only was 199,85±38,10 pg/ml, in the low-intensity-exercise group was 208,46±44,48 pg/ml, in the moderateintensity-exercise group was 232,97±30,40 pg/ml, and in the high-intensity-exercise group was 219,22±26,73 pg/ml. Anova test results found no significant difference (p=0,306) in BNDF level among five groups in this research. Conclusion: swimming exercise with low, moderate, and high intensity has no effect on BDNF level in the hippocampus of fructose-induced mice.

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