SINTESIS 6- [PIROLILMETIL] PINOSTROBIN MELALUI REAKSI MANNICH DENGAN MATERIAL AWAL PINOSTROBIN

I GEDE ARI SUMARTHA, 050911196 (2013) SINTESIS 6- [PIROLILMETIL] PINOSTROBIN MELALUI REAKSI MANNICH DENGAN MATERIAL AWAL PINOSTROBIN. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This research was conducted to synthesize 6-(pyrrolylmethyl)pinostrobin as the target compound to increase bioactivity of pinostrobin by using Mannich reaction. The synthesis itself consists two steps. The first step, pyrrole was reacted with formaldehyde to obtain Schiff base as the intermediate product. The second step was reaction between pinostrobin and the Schiff base that had been obtained from the first step reaction to give reaction product. The product was analysed using IR and H-NMR spectroscopy to conclude that Mannich reaction using pyrrole as secondary amine under this condition did not give the target compound. It is because of the low reactivity of pyrrole as nucleophile and its potency to polymerization under acidic condition.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF 44/13 Sum s
Uncontrolled Keywords: MANNICH REACTION
Subjects: Q Science > Q Science (General) > Q164 Recreations, Home Experiments, etc.
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
I GEDE ARI SUMARTHA, 050911196UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDrs. Hadi Poerwono, Apt., M.Sc., PhD., Drs., Apt., M.Sc., PhD.UNSPECIFIED
Depositing User: shiefti dyah alyusi
Date Deposited: 08 Jan 2014 12:00
Last Modified: 10 Aug 2016 09:07
URI: http://repository.unair.ac.id/id/eprint/9736
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