STEFANUS ARDI KOSASIH, 050911181 (2013) SINTESIS 6-[(DIFENILAMINO)METIL]PINOSTROBIN MELALUI REAKSI MANNICH DENGAN MATERIAL AWAL PINOSTROBIN. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Previous studies showed that pinostrobin have a lot of bioactivities, such as antimicrobial, antiinflamation, and cytotoxic activities. To increase its bioactivity, we introduced aminomethyl substituent into the structure of pinostrobin by using Mannich reaction.. The first step was reaction between diphenylamine as secondary amine and formaldehyde to obtain iminium ion. The second step was reaction between pinostrobin react with iminium ion to give reaction product. The product was purified by column chromatography to give a purified product, which was analysed using IR and H-NMR spectroscopy to determine its structure, and it was concluded that 6-[(diphenylamino)methyl]pinostrobin was not obtained.
| Item Type: | Thesis (Skripsi) | ||||||
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| Additional Information: | KKB KK-2 FF.KF 56/13 Kos s | ||||||
| Uncontrolled Keywords: | MANNICH REACTION | ||||||
| Subjects: | Q Science > QD Chemistry > QD1-999 Chemistry | ||||||
| Divisions: | 05. Fakultas Farmasi > Kimia Farmasi | ||||||
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| Depositing User: | shiefti dyah alyusi | ||||||
| Date Deposited: | 08 Jan 2014 12:00 | ||||||
| Last Modified: | 11 Aug 2016 05:34 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/9748 | ||||||
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