Muhammad Hamdan and Noorhamdani AS and Masruroh Rahayu and Mohammad Hasan Machfoed (2020) The Effect of Ginkgo Biloba (Egb) Extracts on the Expression of Hsp 90, Vegf and Bdnf in the Rattus Novergicus with Lead (Pb) Exposure. Journal of International Dental and Medical Research, 13 (1). pp. 17-22. ISSN 1309-100X

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Abstract

The rapid industrial growth did regrettably create new problems, especially in a heavy amount of lead (Pb) waste. This may cause intoxication, that give rise to health problems specifically in the nervous system. EGb is believed to have neuroprotective effects. Despite lots of studies, the mechanism of action of EGb on repairing brain cell damage due to exposure to Pb remains unclear. The effect of EGb on neuron proteins related to apoptosis and neuronal cell death due to Pb intoxication remains unknown. To determine the effect of Ginkgo biloba extract on the expression of HSP 90, VEGF and BDNF on Rattus novergicus exposed to Pb. This study was experimental by means of randomized experimental post study design. The study population used was male rats, aged 4-5 months, weighing 140-150 grams. The sample of this study was healthy male rats fulfilling the inclusion criteria and exclusion criteria, that was divided into 4 groups. The variables in this study were independent variables, dependent variables, and controlled variables. After the data were obtained and analyzed, a statistical analysis was performed. Based on the acquired data, the HSP 90 levels among groups differed significantly (p=.004), so did the VEGF (p=.030). Likewise, a significant difference among treatment groups was also recorded on the expression of BDNF (p=.004). EGb can reduce HSP 90 expression in rats exposed to lead. EGb can increase VEGF expression in rats exposed to lead. EGb can increase BDNF expression in rats exposed to lead.

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