STUDI PENGGUNAAN ANTIBIOTIKA PADA PASIEN OSTEOMIELITIS (Penelitian dilakukan di Departemen Orthopaedi dan Traumatologi RSUD Dr Soetomo Surabaya )

KAMILIAH DWI KURDIANA, 050911113 (2013) STUDI PENGGUNAAN ANTIBIOTIKA PADA PASIEN OSTEOMIELITIS (Penelitian dilakukan di Departemen Orthopaedi dan Traumatologi RSUD Dr Soetomo Surabaya ). Skripsi thesis, UNIVERSITAS AIRLANGGA.


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Osteomyelitis (OM) is a progressive infection of the bone marrow and cortex resulting in inflammatory destruction of the bone. Osteomyelitis is a disease with causative micro-organisms. Certain major causes of infection such as Staphylococcus aureus (70-80%). These infections continue to cause significant morbidity and difficult to treat. Therefore, on initiating antibiotic therapy as soon as possible is important in reducing long term complications. The standard duration of antibiotic treatment for osteomyelitis is 4-6 weeks. This study is designed to observe the use of antibiotic including type, dose, route, timing of administration, duration of administration, frequency in patient that underwent osteomyelitis and identification of Drug Related Problems (DRPs). The result were compared with literature. This study was conducted retrospectively from period 1st January 2010 to 31st December 2012. In this study, we studied the clinical and laboratories data of 40 patients consisted of 29 males and 11 females with the most age of adult was 13-64 years (80%). The antibiotic therapy that most used including cephalosporin class were ceftriaxone 22 patient (55%) and cefazolin 17 patient (42.5%). From aminoglycosides class were amikacin 14 pasien (35 %) and gentamicin 13 pasien (32.5%). Antibiotic dose were used 15 patient underwent overdose (37.5%), 8 patient underwent underdose, there were 10 patient that underwent frecuency were not appropiate. Route of antibiotic that the most used was intravena 20 patient (50%). The duration of therapy depend on the individual, from 40 patient there were 14 patient that were used parenteral therapy until 2 weeks. While the DRPs found includes adverse drug reaction (1.6%), drug choice problem (20.3%), drug regimen problem (51.6%) and drug interaction (26.6%)

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FK 50/13 Kur s
Uncontrolled Keywords: DRUG UTILIZATION
Subjects: R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
ContributorDra. Aniek Setiya Budiatin, M.Si., Apt., Dra., M.Si., Apt.UNSPECIFIED
Depositing User: shiefti dyah alyusi
Date Deposited: 21 Jan 2014 12:00
Last Modified: 12 Aug 2016 03:30
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