PENGARUH BACLOFEN TERHADAP PROSES SINAPTOGENESIS MENCIT (Mus musculus) MODEL NEUROPATI

RA'ITAH, 050911198 (2013) PENGARUH BACLOFEN TERHADAP PROSES SINAPTOGENESIS MENCIT (Mus musculus) MODEL NEUROPATI. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Pain could be defined as sensoric and bad emotional condition in relation to actual or potential tissue damage. Human can’t live without pain sensation, because pain is such a protective mechanism which happens when body’s tissue is damaged. Pain pathophysiology including complex proccess in brain nerve tissue as result from stimulation reaction which is called as pain experience. Usually pain can be divided into acute and chronic. Neuropathic pain is one of the chronic pains, it can be defined as condition associated with peripheral nerve damage. This research was pretest-posttest control group design using mice as subject. The purpose of this study was to prove the baclofen effectiveness against heat stimulus and synaptogenesis inhibitory in mice with neuropathic models. Mice were randomized into 5 group with seven mice in every group. Neuropathic model was performed by PNL using silk suture 8-0, then 8 day after induction, mice were given NS, baclofen 1, 5, or 10 nmol intrathecally. Pain response were evaluated by gave heat stimulation on the warm plate (50 ± 0.5 ° C). Intrathecal injection of baclofen 1 nmol was significant at day 13 after induction (p=0.029), baclofen 5 nmol significancy different with ligation non treatmen group at day 10 (p=0.02), and baclofen 10 nmol was significant at 8 day after ligation or first day after injection (p=0.029). Histochemistry with HE stained of spinal cord showed some morphologic alteration between sham operated group and ligated grup, also between subjects which received baclofen 1 nmol, 5 nmol and 10 nmol. IHC stainning with synaptophysine showed alteration of synapses naumber in group ligation non treatment and ligation with baclofen 10 nmol as treatment. Result shows that there was correlation between inhibitory synapses with pain behavior in mice, baclofen administration was able to increase latent time of mice.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FK 48/13 Rai p
Uncontrolled Keywords: SYNAPTOGENESIS
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM/NIDN
RA'ITAH, 050911198UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorJunaidi Khotib, S.Si., M.Kes., Ph.D., Apt.UNSPECIFIED
Depositing User: shiefti dyah alyusi
Date Deposited: 21 Jan 2014 12:00
Last Modified: 12 Aug 2016 03:41
URI: http://repository.unair.ac.id/id/eprint/9772
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