A. N. Kristanti and Hery Suwito and Nanik Siti Aminah and K.U. Haq and Helda Dwi Hardiyanti and H. Anggraeni and N. Faiza and R.S. Anto and S. Muharromah (2020) Synthesis of Some Chalcone Derivatives, in vitro and in Silico Toxicity Evaluation. https://rasayanjournal.co.in/admin/php/upload/917_pdf.pdf, 13 (1). 654 -662. ISSN 0976-0083

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Abstract

Chalcone can be synthesized using some methods, but conventional Claisen-Schmidt condensation is still the bestmethod. The objevtives of this study were to synthesize some chalcone derivatives using conventional ClaisenSchmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing molecular docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2´- hydroxychalcone and 4-chloro-2'-hydroxychalcone gave very low IC50, but both did not show potential apoptosis activity, while in docking analysis 4-chloro-2'-hydroxychalcone showing the best results.

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