Rumzil Laili and Nanik Siti Aminah and Tin Myo Than and Yoshiaki Takaya and Ainun Sa’adah and Alfinda Novi Kristanti (2019) Cytotoxicity of Heterophyllene A, the Derivative of Arylbenzofuran from Stem Bark of Artocarpus calophyl. In: Proceedings of the 1st International Conference on Chemical Science and Technology Innovation (ICOCSTI 2019),. Department Of Chemistry Universitas Sumatera Utara, Medan. ISBN 978-989-758-415-2

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Abstract

Exploration of secondary metabolites was the focus of this research, especially of Artocarpus calophylla species to look for a potential cytotoxic agent. An arylbenzofuran derivative compound, namely heterophyllene A was isolated from the stem bark of Artocarpus calophylla. Structure determination of this compound has been elucidated using UV-Vis spectroscopy, 1D, and 2D NMR analysis. This compound has a lower IC50 than ethyl acetate extract. The IC50 of this compound (57,54 µg/mL) to HeLa and (25,80 µg/mL) to T47D cells, ethyl acetate extract (>100 µg/mL) to HeLa and (84,16 µg/mL) to T47D cells.

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