Lilik Maslachah, - and Rahmi Sugihartuti, - (2018) Potency Syzygium cumini L as Adjuvant Therapy on Mice Model Malaria. Iraqi Journal of Veterinary Sciences, 32 (1). pp. 73-80. ISSN 1607-3894, e-ISSN 2071-1255

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Abstract

The objective of study was to prove the potential extract of Syzygium cumini L leaf and steam bark as an adjuvant to malaria modelling mice. Antimalarial effects were assessed by the percentage of parasitemia, growth inhibition 50% dose level (ED50), Parasite Clearance Time (PCT), Recrudescence Time (RT) of Plasmodium berghei. Male albino Swiss mice infected with 1x105 P. beghei Parasite in 0.2 ml intraperitoneally. Treatment with chloroquine 25 mg/kg body weight. chloroquine combination 25 mg/kg body weight with leaf and stem bark extract of Syzygium cumini L dose 600 mg/kg body weight for 4 days and 24 hour after infection, and the is activity as antimalarial and adjuvant therapy were observed. The results showed that the extract of Syzygium cumini L leaf combined with chloroquine gives highly significant result in inhibiting the growth of parasites than thw chloeoquine alone and the extract of Syzzygium cumini L leaf combined with chloroquine gives the Parasite Clearance Time faster and Recrudescence Time (RT) longer than the othher treatment Keywords: Syzygium, Plasmodium, Adjuvant

Item Type:	Article
Uncontrolled Keywords:	Syzygium, Plasmodium, Adjuvant
Subjects:	S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF810 Veterinary parasitology S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF910 Other diseases and conditions
Divisions:	06. Fakultas Kedokteran Hewan > Ilmu Kedokteran Hewan Dasar
Creators:	Creators NIM Lilik Maslachah, - NIDN0006116105 Rahmi Sugihartuti, - NIDN0021026702
Depositing User:	Nn Erna Dwi Indriyani
Date Deposited:	10 Sep 2020 02:10
Last Modified:	15 Dec 2021 03:16
URI:	http://repository.unair.ac.id/id/eprint/98394
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