Effect of Zingiber Officinale Extract and Insulin Administration towards Soluble FMS Like Types of Tyrosine Kinase 1 in Diabetes Mellitus Pregestasional Rattus Norvegicus Models

Hermanto Tri Joewono and Agus Sulistyono and Alif Zahrotin and Aditiawarman (2020) Effect of Zingiber Officinale Extract and Insulin Administration towards Soluble FMS Like Types of Tyrosine Kinase 1 in Diabetes Mellitus Pregestasional Rattus Norvegicus Models. Systematic Reviews in Pharmacy, 11 (2). pp. 699-702. ISSN 09758453

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I. 12. Effect of Zingiber Officinale Extract and insulin Administration Towards Soluble FMS-Like Types of tyrosine Kinase-1 In Diabetes Mellitus Pregestasional Rattus Norvegicus Models.pdf

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Effect of Zingiber Officinale Extract.pdf

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Effect of Zingiber Officinale Extract and insulin Administration Towards Soluble FMS-Like Types of tyrosine Kinase-1 In Diabetes Mellitus Pregestasional Rattus Norvegicus Models.pdf

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Official URL: http://www.sysrevpharm.org//index.php?mno=118840

Abstract

The perinatal mortality rate increases 20 times in pregestational diabetes mellitus (PGDM) women with preeclampsia complications associated with changes in soluble fms-like tyrosine kinase-1 (sFlt-1) levels. The study analyzed the differences of effect of Zingiber officinale extract and insulin administration on the sFlt-1 level of Rattus norvegicus PGDM models. Rattus norvegicus were divided into five groups. The sFlt-1 level concentration was examined by ELISA. There was statistically significant increase of sFlt-1 levels in all groups (1.24±0.16, 1.58±0.12, 1.73±0.30, 1.98±0.47, 2.34±0.23, p = 0.001 for negative control, positive control, insulin treatment, Z. officinale extract treatment, insulin and Z. officinale extract combination respectively). There was significant difference of sFlt-1 between negative control and treatment groups and between positive control and treatment groups. The most different group was the negative control group with the insulin and Z. officinale extract combination with p = 0.001 in MD = -1. The presence of Z. officinale extract can be used as a single therapy or a combination with insulin for PGDM for decreased risk factor of PGDM, such as preeclampsia.

Item Type: Article
Uncontrolled Keywords: Pregestational diabetes mellitus, insulin, Zingiber officinale, sFlt-1
Subjects: R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Divisions: 01. Fakultas Kedokteran > Ilmu Kebidanan dan Kandungan
Creators:
CreatorsNIM
Hermanto Tri JoewonoNIDN8817900016
Agus SulistyonoNIDN8810800016
Alif ZahrotinUNSPECIFIED
AditiawarmanNIDN8837700016
Depositing User: hanif kurniawan
Date Deposited: 08 Oct 2020 02:18
Last Modified: 08 Oct 2020 02:18
URI: http://repository.unair.ac.id/id/eprint/99200
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