Nurul Damayanti (2020) Efek Atorvastatin Terhadap LPL (Lipoprotein Lipase)Dan Profil Lipid Pada Pasien Anak Sindrom Nefrotik Refrakter Dengan Hiperlipidemia (Penelitian dilakukan di Poli Anak Nefrologi RSUD Dr. Soetomo). Thesis thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Introduction: Hyperlipidemia occurs in SN caused by decrease level of lipoprotein lipase (LPL). LPL isan enzyme that is directly involved and a determinant rate in lipid metabolism through twocholesterol metabolism pathways. In previous study, lipid lowering agents haven’t alwaysgiven however in the literature, however, in the literature, statin administration remainscontroversial in the condition of refractory nephrotic syndrome. Objectives: To analyze the effect and the relationship of atorvastatin on lipid profiles (total cholesterol,LDL, TG, HDL) and LPL. Methods: This study has met the ethical eligibility with No. 1668/KEPK/XI/2019. A RCT doubleblind, pre and post test control group study of 31 children nephrotic syndrome refracter withhyperlipidemia patients divided into 2 groups. The first group (n = 18 patients) treated withplacebo and the other group (n = 13 patients) treated with atorvastatin. Observations carriedout for four weeks. The efficacy of therapy was measured by lipid profile and LPL.Results: We evaluated after 4 weeks, the total cholesterol and LDL from pre and post therapy of eachgroup show the significant differences (p<0,05). However, TG and HDL did not make asignificant difference. The LPL increased in the atorvastatin group but did not make asignificant difference. There is no significant difference between changes in lipid profile andchanges in LPL levels two group.Conclusion: Atorvastatin therapy significantly decreases total cholesterol and LDL but not in TG. Incontrast to total cholesterol, LDL and TG, administration of atorvastatin increases HDL andLPL. The relationship between LPL levels with total cholesterol, LDL, TG, and HDL levelshas not been proven. 1. Agrawal, S., Zaritsky, J., Fornoni, A. and Smoyer, W. 2018. Dyslipidemia in NephroticSyndrome: Mechanisms and Treatment. Nature Reviews Nephrology, vol 14, pp. 57-70. 2. Alatas, H., Trihono, PP. PP., Tambunan, T &Pardede, S. O. 2012. Konsensus TataLaksanaSindromNefrotikIdiopatikpadaAnak. Jakarta: BadanPenerbitIkatanDokterAnak Indonesia, pp. 1-36. 3. Anandkumar, S et al. 2016. Clinical Efficacy Study of Atorvastatin, Simvastatin andPravastatin in Hyperlipidemic Patients. International Journal of Pharmacy &Pharmaceutical Research, vol. 6 (4), pp. 523-530. 4. Andrade, Junior, M. 2018. Lipoprotein Lipase: A General Review. Insights in EnzymeResearch, vol.2 No.1:3, pp. 1-14. 5. Arshad, A. 2014. Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-LabelRandomized Trial. Journal of Lipids, pp. 1-5. 6. Astuti, K. D., Muryawan, M. H., Mellyana, O. 2015. Correlation Between Lipid Profile andC-reactive protein in Children with Nephrotic Syndrome. PaediatricaIndonesiana,vol. 55, No. 1, pp. 1-6. 7. Avis HJ, Vissers MN, Stein EA, et al. Asystematic review and meta-analysis of statintherapy in children with familial hypercholesterolemia. 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Item Type: | Thesis (Thesis) | ||||||||||||
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Additional Information: | KKC KK TFK.07-20 Dam e | ||||||||||||
Uncontrolled Keywords: | atorvastatin, lipoprotein lipase (LPL), lipid profile (total cholesterol, LDL, TG, HDL) | ||||||||||||
Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica | ||||||||||||
Divisions: | 05. Fakultas Farmasi > Farmasi Klinis | ||||||||||||
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Depositing User: | Tatik Poedjijarti | ||||||||||||
Date Deposited: | 15 Dec 2020 03:12 | ||||||||||||
Last Modified: | 15 Dec 2020 03:13 | ||||||||||||
URI: | http://repository.unair.ac.id/id/eprint/101644 | ||||||||||||
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