Compressive strength and porosity tests on bovine hydroxyapatitegelatin-chitosan scaffolds

Nadia Kartikasari and Anita Yuliati and Indah Listiana Kriswandini (2016) Compressive strength and porosity tests on bovine hydroxyapatitegelatin-chitosan scaffolds. Dental Journal (Majalah Kedokteran Gigi), 49 (3). pp. 153-157. ISSN 1978-3728

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Background: Degenerative diseases, aggressive Periodontitis, trauma, jaw resection, and congenital abnormalities can cause defects in jaw bone. The surgical procedure for bone reconstruction currently performed is bone regeneration graft (BRG). Unfortunately, this procedure still has many disadvantages. Thus, tissue engineering approach is necessary to be conducted. The main component used in this tissue engineering is scaffolds. Scaffolds used in bone regeneration is expected to have appropriate characteristics with bone, such as high porosity and swelling ratio, low degradation rates, and good mechanical properties. For those reasons, this research used scaffolds made from bovine hydroxyapatite (BHA), gelatin (GEL), and chitosan (K)/BHA-GEL-K as one of biomaterial candidates for bone regeneration. Purpose: This study aimed to determine compressive strength value and porosity size of BHA-GEL-K scaffolds. Method: Compressive strength of BHA-GEL-K scaffolds was tested using autograph with speed 10 mm/ min with a load cell compress machine of 100 kN. Compressive strength was calculated by force divided to surface area. Porosity test was measured using SEM. Scaffold were coated with Pb and Au, then the porosity size is calculated with SEM at 100x magnification. Result: BHA-GEL-K scaffolds had a mean compressive strength value of 174.29 kPa and a porosity size of 31.62 + 147.06 lm. Conclusion: It can be concluded that BHA-GEL-K scaffolds has a good compressive strength, but not yet resemble real bone mass, while porosity of BHA-GEL-K scaffold is appropriate for bone tissue regeneration application.

Item Type: Article
Uncontrolled Keywords: scaffolds; bovine hydroxyapatite; gelatin; chitosan; compressive strength; porosity
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Dental Material
Nadia KartikasariNIM021414153005
Anita YuliatiNIDN0009075803
Indah Listiana KriswandiniNIDN0030106303
Depositing User: Rudy Febiyanto
Date Deposited: 28 Dec 2020 02:31
Last Modified: 28 Dec 2020 02:31
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