D. Lamondo and Agoes Soegianto and A. Abadi and S. Keman (2014) Antioxidant effects of Sarang Semut (Myrmecodia pendans) on the apoptosis of spermatogenic cells of rats exposed to plumbum. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5 (4). pp. 282-294.

Abstract

Active compounds in Sarang Semut are flavonoids, tannins, polyphenols, and tocopherols which serve as primary antioxidants in the body. The existence of these antioxidants enables Sarang Semut to be used to address the free radicals induced by plumbum (Pb). The objective of this study was to analyze antioxidant effects of Sarang Semut on the number of apoptosis spermatogenic cells, malondialdehyde (MDA) levels and superoxide dismutase (SOD) of serum. Compared to the control group, the number of apoptosis of spermatogenic cells and the MDA level of serum of the group exposed to Pb showed a significant increase (P < 0.05), and the level of SOD of serum showed a significant decrease (P < 0.05). After the provision of the extract and fraction of Sarang Semut, the exposed group showed a significant decrease (P < 0.05) in the number of spermatogenic cells and MDA level of serum, and a significant increase (P < 0.05) in the level of SOD. Antioxidants of Sarang Semut can decrease the number of apoptosis spermatogenic cells and the MDA level of serum, and increase the level of SOD serum of rats exposed to Pb.

Actions (login required)

View Item