Rizky Fitri Fauzia (2015) Aktivitas Antibakteri Kombinasi Mikropartikel Susu Probiotik Dan Mikropartikel Ekstrak Air Daun Jambu Biji Terhadap Escherchia Coli. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Purpose of this research is to see the activity of combination probiotic microparticles and aqueous extract of guava leaf against Escherichia coli. Four different formula probiotic Lactobacillus sp microparticles (P) and aqueous extract of guava leaves microparticles (J) were prepared. P1 and J1 without matrix HPMC K100LV, P2 and J2 used matrix HPMC K100LV 0,1%, P3 and J3 used matrix HPMC K100LV 0,2%, P4 and J4 used matrix HPMC K100LV 0,3%. Activity test of both microparticles performed at gastroinstestinal pH conditions, that is gastric pH and intestine pH. The microparticles are inserted to holes of agar that added bacteri test Escherichia coli dan incubated for 24 hours at 37°C. Probiotic Lactobacillus sp microparticles that have highest inhibitory activity is P2 with 7,70 ± 1,11 mm, while the highest for aqueous extract of guava leaves microparticles is J2 with 11,15 ± 0,23 mm. Then performed inhibitory activity test to combination of probiotic microparticles and aqueous extract of guava leaves against Escherichia coli and the result showed the inhibitory activity 11,73 ± 0,10 mm. From statistical test shown that inhibitory activity of those micropraticles was significant different from probiotic Lactobacillus sp microparticles, and has not significant different from aqueous extract of guava leaves microparticles. It can be concluded that combination of probiotic microparticles and aqueous extract of guava leaves do not have a synergistic effect.

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