Agus Sulistyono and Andhita Hapsari and Erry Gumilar Dachlan and Hermanto Tri Joewono and M. Nadir Abdullah and Aditiawarman and Ernawati and Budi Wicaksono and Khanisyah Erza Gumilar and Manggala Pasca Wardhana and Nareswari Cininta I and Rozi Aditia and Muhammad Ilham Aldika Akbar (2018) The characteristic of PE (preeclampsia) complication at lupus on pregnancy. Pregnancy Hypertension, 13 (S.1). pp. 119-120. ISSN 2210-7789

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Abstract

Background Indonesia had the serious challenge of highly maternal mortality over last ten years reflecting the real national health problem. There was 305 maternal death/100.000 deliveries, where 3 major possible cause of PE, PPH and infection persisted. Recently the new comer of diseases was standing tightly behind them: lupus on pregnancy. Material & Method This was a retrospective study from medical records.. Fifty-two cases of Lupus from 4592 pregnancy during 4 years (1.13%) have been observed in DR. Soetomo Teaching Hospital (tertiary hospital) Surabaya, Indonesia from January 2013 through December 2016. Results Sixteen cases of lupus were complicated by PE (30.7%), and 37.5% cases with Lupus Nephritis (that mostly showing increased serum creatinin level > 1.4 mg%). The maternal age were 25–34 years old (62.5%) and 62.5% were multigravida. Almost half cases (43.75%) got flare, leading to 25% early termination, while the remaining casesed (75%) were conservatively managed until 34 weeks gestation. Fetal outcome reported as 11 cases (68.75%) having birthweight > 2 kg, with 37.5% asphyxia (low apgar score). Discussion Pregnancy was discouraged in women affected by SLE, due to the disease becoming more aggresive during pregnancy and a poor pregnancy outcome was frequently reported. During pregnancy, the maternal immune system adapts to allow the growth of a semi-allogenic fetus. Significant immunological changes occur including suppression of type-2 helper cells (Th2), but the upregulation of Th1 cytokines in pregnancy may increase the risk for Th1-mediated diseases. The aboved concept was reflected at our study where most cases were sucessfully managed conservative until 34 weeks gestation and majority baby born with birthweight > 2 kg. Conclusions Our results suggest that lupus women are much more likely to develop worsening maternal spesifically preeclampsia and fetal outcomes when they become pregnant.

Item Type:	Article
Uncontrolled Keywords:	Preclamsia
Subjects:	R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics
Divisions:	01. Fakultas Kedokteran > Ilmu Kebidanan dan Kandungan
Creators:	Creators NIM Agus Sulistyono NIDN8810800016 Andhita Hapsari UNSPECIFIED Erry Gumilar Dachlan UNSPECIFIED Hermanto Tri Joewono NIDN8817900016 M. Nadir Abdullah UNSPECIFIED Aditiawarman NIDN8837700016 Ernawati NIDN0016077710 Budi Wicaksono UNSPECIFIED Khanisyah Erza Gumilar NIDN0005088405 Manggala Pasca Wardhana NIDN0020118404 Nareswari Cininta I UNSPECIFIED Rozi Aditia UNSPECIFIED Muhammad Ilham Aldika Akbar NIDN0018018203
Depositing User:	arys fk
Date Deposited:	07 Jan 2021 03:23
Last Modified:	07 Jan 2021 03:23
URI:	http://repository.unair.ac.id/id/eprint/102635
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