Ishak Zakaria and Norizan Ahmat and Faridahanim M. Jaafar and Aty Widyawaruyanti (2012) Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba. Fitoterapia, 83 (5). pp. 968-972. ISSN 0367-326X

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Abstract

A new flavanone derivative, malaysianone A (1), four prenylated flavanones, 6-prenyl-3′-methoxyeriodictyol (2), nymphaeol B (3), nymphaeol C (4) and 6-farnesyl-3′,4′,5,7-tetrahydroxyflavanone (5), and two coumarins, 5,7-dihydroxycoumarin (6) and scopoletin (7), were isolated from the dichloromethane extract of the inflorescences of Macaranga triloba. The structures of these compounds were elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D), UV, IR and mass spectrometry. The cytotoxic activity of the compounds was tested against several cell lines, with 5 inhibiting very strongly the growth of HeLa and HL-60 cells (IC50: 1.3 μg/ml and 3.3 μg/ml, respectively). Compound 5 also showed strong antiplasmodial activity (IC50: 0.06 μM).

Item Type:	Article
Uncontrolled Keywords:	Euphorbiaceae, Macaranga triloba, Flavonoids, Malaysianone A, AntiplasmodialCytotoxic
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi
Creators:	Creators NIM Ishak Zakaria UNSPECIFIED Norizan Ahmat UNSPECIFIED Faridahanim M. Jaafar UNSPECIFIED Aty Widyawaruyanti NIDN0026046210
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	23 Feb 2021 05:27
Last Modified:	23 Feb 2021 05:27
URI:	http://repository.unair.ac.id/id/eprint/102674
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