GEMILANG HARDYANPUTRINDA, 051111031 (2016) PENGARUH SUBSTITUEN 2-METOKSI PADA SINTESIS TURUNAN 2-HIDROKSIBENZOHIDRAZIDA DENGAN IRADIASI GELOMBANG MIKRO GEMILANG HARDYANPUTRINDA. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

N’-benzylidene-2-hydroxybenzohydrazide and N’-(2- methoxybenzylidene)-2-hydroxybenzohydrazide are hydrazide derived compounds that could be made from methyl salicylate. The aim of this research is to determine the influence of 2- methoxy substituent in the synthesis of N’-(2-methoxybenzylidene)- 2-hydroxybenzohydrazide through the yields of synthesis comparisons with N’-benzylidene-2-hydroxybenzohydrazide by microwave irradiation. N’-(2-methoxybenzylidene)-2-hydroxybenzohydrazide synthesized from structure modification of methyl salicylate through 2 phases of reaction, nucleophilic acyl substitution to produce 2-hydroxybenzohydrazide and nucleophilic addition to produce target compound. Methoxy group influences carbonyl reactivity through resonance and steric effect in nucleophilic addition. N’-benzylidene-2-hydroxybenzohydrazide is white, needleshaped crystal (88 ± 2.5)% and N’-(2-methoxybenzylidene)-2- hydroxybenzo-hydrazide is white round solids (76 ± 3.5)%. Concluded that 2-methoxy substitutient decrease carbonyl reactivity in nucleophilic addition of N’-(2-methoxybenzylidene)-2-hydroxybenzohydrazide synthesis.

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