Saryono, S. and Taufik, A. and Proverawati, A. and Ferry Efendi (2019) Dietary supplementation of Phoenix dactylifera L. Seeds decreases pro-inflammatory mediators in CCl4-induced rats. Journal of HerbMed Pharmacology, 8 (3). pp. 212-217.

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Abstract

Introduction: Low immunity causes the body to become more easily infected, resulting in inflammation. If the immune system is functioning properly, this inflammation will end in healing. The immune system has a protective role in the body, and its anti-inflammatory role is vital. During trauma, the initial immune response is marked by inflammation. The use of date-seed extract, although not steeped date seeds, has been studied as an anti-inflammatory agent. This study is aimed at demonstrating the anti-inflammatory effect of steeped date seeds (Phoenix dactylifera L.) in rats with CCl4-induced inflammation. Methods: This experiment included a pre- and post-test with control group design. Male Wistar rats (approximately 2�3 months of age, ranging in weight from 150 to 200 g) were assigned to the following groups: negative control (NC), positive control (PC), T1 treatment dose 1 g/kg, T3 treatment dose 3 g/kg, T5 treatment dose 5 g/kg, and healthy control (HC). Groups 1�5 were subjected to CCl4 induction at a single dose of 2 mL/kg before treatment. The levels of tumor necrosis factor (TNF-α), glutathione (GSH), and gamma interferon (IFN-γ) were compared in groups using one-way analysis of variance (ANOVA), followed by a least significant difference (LSD) post hoc test for comparisons between means. Results: Levels of tumor necrosis factor (TNF-α), GSH, and IFN-γ were significantly different among the HC and treatment groups after CCl4 induction. After 14 days of steeped date-seed treatment, TNF-α decreased, but GSH and IFN-γ levels increased significantly (P = 0.001). Conclusion: Administration of steeped date seeds at a dose of 5 g/kg can increase GSH and IFN-γ, and decrease TNF-α, the strongest inflammatory marker in CCl4-induced rats. The findings of this study indicate that date-seed supplementation can support body immunity by regulating pro-inflammatory mediators. © 2019 Nickan Research Institute. All rights reserved.

Item Type:	Article
Additional Information:	cited By 5
Uncontrolled Keywords:	alanine aminotransferase; antiinflammatory agent; aspartate aminotransferase; carbon tetrachloride; creatinine; dexamethasone; gamma interferon; glutathione; Phoenix dactylifera seed extract; plant extract; tumor necrosis factor; unclassified drug, animal experiment; animal model; animal tissue; antiinflammatory activity; Article; bactericidal activity; controlled study; cytotoxic T lymphocyte; date (fruit); diet supplementation; drug dose comparison; enzyme linked immunosorbent assay; immune response; immune system; inflammation; male; nonhuman; plant seed; rat
Divisions:	Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:	Creators NIM Saryono, S. UNSPECIFIED Taufik, A. UNSPECIFIED Proverawati, A. UNSPECIFIED Ferry Efendi UNSPECIFIED
Depositing User:	Ika Rudianto
Last Modified:	03 Feb 2021 05:34
URI:	http://repository.unair.ac.id/id/eprint/103546
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