Genotoxic effects of exposure to urban traffic related air pollutants on children in Klang Valley, Malaysia

Hisamuddin, N.H. and Juliana Jalaludin and Yusof, A.N. and Abdul Rohim Tualeka (2020) Genotoxic effects of exposure to urban traffic related air pollutants on children in Klang Valley, Malaysia. Aerosol and Air Quality Research, 20 (12). pp. 2614-2623.

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Abstract

Traffic-related air pollutants (TRAPs) are currently increasing due to the increment of vehicle numbers in Malaysia. The emission of pollutants from these vehicles have genotoxic properties that can potentially induce genetic damage in human. In this study, micronuclei assay is used to determine the potential genotoxic exposure by assessing the presence of micronuclei frequency (MN) in buccal cells. The specific objective of this study is to determine the association between TRAPs and frequency of MN among school children in Klang Valley. A comparative cross-sectional study was conducted among primary school children (9�11 years old) in high-density traffic area (n = 94, Kuala Lumpur) and low-density traffic area (n = 94, Hulu Langat). A questionnaire was distributed to the parents to obtain respiratory symptoms information. Buccal cells were analyzed to determine the frequency of micronuclei. Air quality assessment was carried out in a total of 6 schools (consisted of exposed and comparative groups) by using TSI DustTrak DRX Aerosol Monitor 8534 for measurement of PM2.5 and PM10, LaMotte�s Model BD Air Sampling Pump for measurement of Nitrogen dioxide (NO2) and Sulphur dioxide (SO2), ppbRAE 3000 for total Volatile Organic Compound (TVOC) and TSI Q-TRAK 7565 for measurement of Carbon dioxide (CO2) and Carbon monoxide (CO). The concentrations of PM10, PM2.5, NO2, SO2, TVOC and CO at exposed schools were significantly higher (p < 0.005). compared to those in comparative schools. All pollutants were significantly associated (p < 0.001) with respiratory symptom phlegm and MN frequency. Additionally, the MN frequency in the exposed group was significantly higher (p < 0.001) than in the comparative group. All in all, this study demonstrated that air pollutants, especially NO2 and CO, have significantly influenced the MN frequency among children in primary schools. This study suggested that exposure to TRAPs among Malaysian school children has increased the risk for respiratory complications with the formation of MN. © The Author(s).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Air quality; Carbon dioxide; Carbon monoxide; Nitrogen oxides; Volatile organic compounds, Air quality assessment; Cross-sectional study; Genotoxic effects; Nitrogen dioxides; Primary school children; Respiratory symptoms; Total volatile organic compounds; Traffic-related, Sulfur dioxide, atmospheric pollution; child health; detection method; fuel cell; genetic analysis; genotoxicity; health risk; pollution exposure; risk factor; symptom; traffic emission; urban pollution, Hulu Langat; Klang Valley; Kuala Lumpur; Malaysia; Selangor; West Malaysia, Varanidae
Divisions: Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:
CreatorsNIM
Hisamuddin, N.H.UNSPECIFIED
Juliana JalaludinUNSPECIFIED
Yusof, A.N.UNSPECIFIED
Abdul Rohim TualekaUNSPECIFIED
Depositing User: Ika Rudianto
Last Modified: 03 Feb 2021 05:35
URI: http://repository.unair.ac.id/id/eprint/103609
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