Nurwasis and Diana Yuliawati and Evelyn Komaratih and Heriyawati (2019) The effect of subconjunctival bevacizumab on angiogenesis in rabbit model. Folia Medica Indonesiana, 55 (4). pp. 290-294. ISSN 2355-8393

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Abstract

The wound healing process is major cause of glaucoma surgery failure and enhances the incapability of controlling the IOP. This aim of study was to evaluate the angiogenesis effect of Bevacizumab injection on the amount and density of blood vessels in the rabbit model after trabeculectomy. It was a true experimental study using 16 eyes of 16 New Zealand White Rabbit (Oryctolagus cuniculus) that divided into two groups. The control group was treated with 0.05 ml of Balanced Saline Solution (BSS). The experimental group was treated with subconjunctival injection of 1.25 mg Bevacizumab in 0.05 BSS. All rabbit was sacrificed, and the eye was enucleated. Thus, the bleb area was dissected after 14 days. Histopathological analysis was performed to evaluate the amount and density of blood vessels. The mean amount of blood vessels in the control group was 22.63 ± 11.02, and the experimental group was 14,75 ± 4.92 (p=0.043). The mean of blood vessel density in the control group was 19.10 ± 1.69 %, and the experimental group was 16.53 ± 2.90 % (p=0.029)%. There was a statistically significant difference between the two groups (p<0.05). Subconjunctival bevacizumab in the rabbit model reduces the amount and density of blood vessels compared with subconjunctival BSS injection.

Item Type:	Article
Uncontrolled Keywords:	Angiogenesis, bevacizumab, amount of blood vessel, density of blood vessel, trabeculectomy
Subjects:	R Medicine > R Medicine (General) R Medicine > RE Ophthalmology
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Mata
Creators:	Creators NIM Nurwasis NIDN8859130017 Diana Yuliawati UNSPECIFIED Evelyn Komaratih NIDN8830900016 Heriyawati UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	08 Jun 2021 08:16
Last Modified:	08 Jun 2021 08:16
URI:	http://repository.unair.ac.id/id/eprint/104166
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