UNSPECIFIED (2020) Perbandingan Karakterisasi Dan Disolusi Kompleks Inklusi Senyawa Obat-Hidroksipropil-β-Siklodekstrin (Hpβcd) Yang Dibuat Dengan Metode Freeze Drying Dan Spray Drying Literature Review. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Solubility is one of the physicochemical properties that affect the absorption of drug in the gastrointestinal tract, which given orally. However, the drugs with low solubility cause dissolution rate and low bioavailability, resulting in more prolonged onset of action. Therefore, the cyclodextrin-inclusion complex formed to increase solubility and dissolution. The literature review aims to compare the results of inclusion complex-hydroxypropyl-β-cyclodextrine (HPβCD) characterization and dissolution with freeze drying and spray drying methods. A comprehensive study was defined to obtain data for the inclusion complex characterization (DSC, PXRD, FTIR spectra, SEM) and dissolution test with freeze-drying and spray-drying methods. The combination of 5 keywords from the relevant literature were searched from electronic databases such as Google Scholar, ScienceDirect, and PubMed. Analysis convinced that the characteristics of the inclusion complex from the freeze-drying method and the spray drying method could be distinguished. The difference in characteristic results is shown by the DSC thermogram which provides a more significant shift in melting temperature confirmed the finding results and the PXRD diffractogram with a higher degree of amorphous state of the frezze drying method.The dissolution rate of the inclusion complex with the freeze drying method is higher than the spray drying method.

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