Uli Rumondang Nehemia Manihuruk (2020) Pengaruh Pemberian Ekstrak Bawang Hitam (Allium sativum L.)Terhadap Kadar Malondialdehid (MDA) Darah Yang Diberi Paparan Stres Panas Pada Mencit Jantan (Mus musculus). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This study aimed to determine the effect of black garlic extract (Allium sativum L) on the levels of malondialdehyde (MDA) in the blood exposed to heat-stress in male mice (Mus musculus). There were 25 mice used in this study which were divided into five groups, each of which consisted of five mice. This research group consisted of K- (control group, without heat stress), K+ (with heat stress of 400C + distilled water), P1 (with heat stress of 400C + black garlic extract of 125mg/kg body weight), P2 (heat stress of 400C + black garlic extract of 250mg/kg body weight), P3 (heat stress 400C + black garlic extract of 500mg/kg body weight). The black garlic extract was administered orally every day for 54 days after exposure to heat stress of 400C. After 54 days of treatment, the mice were euthanized and their blood was taken intracardially for MDA laboratory examination using Thiobarbituricacis (TBA). The data in the study were analyzed using one-way ANOVA (Analysis of Variance) which show a significant difference between negative control (K-) (x- : 2.268± 0.685nmol/mL) and positive control (K+) (x- : 13.075c ± 2.846nmol/mL). In addition, there is a significant difference between the positive group and the P3 group (3.329 ± 1.499nmol/mL). In conclusion, black garlic extract (Allium sativum L) at a dose of 500mg/kg body weight (P3) is an ideal dose that can be used to reduce the levels of Malondialdehyde (MDA) in the blood of mice exposed to heat stress.

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