Nurullia Tanjung (2020) Uji Aktivitas Ekstrak Daun Sida Rhombifolia L. Sebagai Antivirus Hepatitis C. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Sida rhombifolia L. is a plant of the Malvaceae family which has been used as a traditional medicine for curing jaundice. Previous research reported that S. rhombifolia L. seed extract possessed hepatoprotective. This study aimed to determine the antiviral activity of S. rhombifolia against hepatitis C virus. In vitro anti-viral activity was conducted to ethanol, n-hexane, dichloromethane, and methanol extracts of S. rhombifolia L. leaves. Various concentrations of extracts were inoculated onto the Huh7it infected cells. Cytotoxicity analysis was evaluated by MTT(3-[4,5-dimethylthiazol-2-yl]-5-[3carboxymethoxyphenyl]-2-[4-sulfophenyl]-2H-tetrazolium) assay. The result was obtained that extracts of ethanol, n-hexane, dichloromethane, and methanol of S. rhombifolia L. possessed strong activity against HCV with IC50 value of 2.0 ± 0.6 μg/ml; 1.5 ± 0.2 μg/ml; 0.5 ± 0.1 μg/ml; 0.8 ± 0.8 μg/ml, respectively. The cytotoxicity test showed no toxic effect with CC50 value of ethanol extract was 387,9 ± 8,6 μg/ml. Those results suggest that ethanol extract, n-hexane, dichloromethane, and methanol of S. rhombifolia L. leaves are active as anti-hepatitis C virus.

Item Type:	Thesis (Skripsi)
Additional Information:	KKC KK FF.FT.03-21 Tan u
Uncontrolled Keywords:	Sida rhombifolia L., hepatitis C virus, cell culture
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:	Creators NIM Nurullia Tanjung NIM051611133027
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Tutik Sri Wahyuni NIDN0025107704 Thesis advisor Neny Purwitasari, - NIDN0019048006
Depositing User:	Jadik jdkyanto Wijayanto
Date Deposited:	23 Sep 2021 05:08
Last Modified:	23 Sep 2021 05:08
URI:	http://repository.unair.ac.id/id/eprint/104718
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