Elda Yuliana Dwi Lestari (2020) Aktivitas Antimalaria Hasil Subfraksinasi Dari Fraksi 6 Ekstrak Diklorometana Kulit Batang Cratoxylum Sumatranum (Jack) Bl. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Malaria is a disease caused by Plasmodium parasites. In the prevention of malaria, it is necessary to make efforts to develop new anti-malarial drugs by using natural ingredients. Cratoxylum spesies was one of the plants that showed potential antimalarial activity. The purpose of this study was to determine the antimalarial activity the result of subfractionation from the fraction of 6 dichloromethane extracts of the stem bark of Cratoxylum sumatranum (Jack) Bl. The fraction of 6 dichloromethane extract of the stem bark of C. sumatranum (Jack) Blume was fractionated using the preparative Thin Layer Chromatography method on RP18 plates with methanol-water mixed eluent (9:1), obtained 10 subfractions (SB 6.1-SB 6.10). All subfraction results obtained from the preparative Thin Layer Chromatography method were samples tested with the Lactate Dehydrogenase (LDH) test at a concentration of 4 μg/mL and continued with the determination of IC50 at a concentration of 10 μg/mL; 4 μg/mL; 1μg/mL; 0.4 μg/mL; 0.1 μg/mL; 0.04 μg/mL; 0.01 μg/mL; and 0.004 μg/mL. Subfraction 4 (IC50 value 0.35 ± 0.02 μg/mL) and subfraction 7 (IC50 value 0.74 ± 0.02 μg/mL) had antimalarial activity in inhibiting the growth of Plasmodium falciparum in the LDH assay method while the other subfractions did not active. Subfraction 4 has the highest antimalarial activity compared to the IC50 value of subfraction 7 and is included in the strong active category as an antimalarial because it has an IC50 value ≤ 5μg/ mL and possibly contains xanthones.

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