Nida Septioning Sukma (2020) Uji Aktivitas Ekstrak Daun Acacia Mangium Willd. Sebagai Antivirus Hepatitis C Secara In Vitro. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Acacia mangium Willd is a plant from Mimosaceae family that has several compounds including alkaloids, flavonoids, tannins, phenolics, glycosides. A. mangium Willd. was reported to contain with quercetin and procyanidin which possessed antihepatitis C virus (anti-HCV) activity with IC50 value of 1.5 μg/ml and EC50 of 2.06 μM. Crude drug of A. mangium Willd. leaves was extracted with 96% ethanol and successively extraction with n-hexane, dichloromethane, methanol. Anti-HCV activity was tested by inoculated the extract and fraction onto Huh7it cells-HCV infected at a concentration of 0.01; 0.1; 1; 10; 50; 100 μg/ml. The result was showed that IC50 dichloromethane fraction, methanol fraction, n-hexane extract and ethanol extract 96%, were 0.22 ± 0.03 μg/ml; 2.68 ± 0.09 μg/ml; 2.94 ± 0.09 μg/ml; 4.45 ± 0.06 μg/ml, respectively. The mode of action of extract A. mangium Willd. leaves was evaluated to determine the action of extract in the entry or post entry of hepatitis C life cycle. The ethanol extract of A. mangium Willd. leaves showed stronger inhibition in the post entry than entry step with percentage inhibition 56.25% at the concentration of 30 μg/mL. Cytotoxicity test was also carried out in this study with the MTTassay method and it was revealed that 96% ethanol extract of A. mangium Willd. leaves had not toxic effect with CC50 value higher than 400 μg/ml. These results indicated that the extract and fractions of A. mangium Willd. leaves have anti-HCV activity and provide potential to be developed as a hepatitis C agents.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKC KK FF.FT.19-21 Suk u | |||||||||
| Uncontrolled Keywords: | Antihepatitis C virus, Acacia mangium Willd., extract, fraction | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Jadik jdkyanto Wijayanto | |||||||||
| Date Deposited: | 23 Sep 2021 05:10 | |||||||||
| Last Modified: | 23 Sep 2021 05:10 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/104765 | |||||||||
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