Kadek Agus Heryana Putra (2020) Efektivitas Pemeliharaan Anestesi Propofol Dibandingkan Sevofluran Dalam Mencegah Kejadian Agitasi Pascaanestesi Pada Pasien Pediatri. Other thesis, Universitas Airlangga.

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Abstract

Background: Emergence agitation (EA) is still seen as a relevant clinical problem by experienced pediatric anesthesiologists. EA increases the morbidity of pediatric patients. Many techniques have been used to reduce the incidence of EA. In this study we used continuous infusion of propofol given intravenously after inhalation induction with sevoflurane to maintain anesthesia. Objective: This study was conducted to analyze the effectiveness of maintaining anesthesia with intravenous propofol to prevent the incidence of emergence agitation compared to inhalation of sevoflurane in pediatric patients. Methods: After obtaining approval from ethics committee, patients aged 5–18 years, American Society of Anesthesiologists class (ASA) I or II, scheduled for surgery or non-surgery were randomized to receive propofol infusion or sovoflurane to maintain anesthesia. Both groups received sevoflurane inhalation induction. The degree of EA is assessed when arriving at the recovery room, every 10 minutes for 60 minutes obtained from observations using the PAED scale. Pain was observed using the FLACC scale. The results were analysed statistically using t Tets, Mann-Whitney and Chi square test. Results: One hundred and eighteen children completed the study. Propofol decreased the incidence of EA compared with the sevoflurane group (propofol, 29.6%; Sevoflurane, 65.5%; P⩽0.001; relative risk [RR], 0.45; 95% confidence interval [CI], 0.289 to 0.706). The incidence of pain was similar in the 2 groups (propofol, 18.5%; Sevoflurane, 23.4%; P=0.515; RR, 0.790; 95% CI, 0.387 to 1.613). Conclusion: The use of intravenous propofol for maintenance of anesthesia is more effective in preventing the occurrence of EA when compared to maintaining anesthesia using sevofluran inhalation in pediatric patients.

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