Dwi Murtiastutik, - and Cita Rosita Sigit Prakoeswa, - and Indah Setyawati Tantular, - and Evy Ervianti, - and Afif Nurul Hidayati, - and Muhammad Yulianto Listiawan, - (2021) Correlation between CD4 T lymphocyte and Candida Species Counts In Oral Candidiasis Patients with HIV / AIDS. Indian Journal of Forensic Medicine & Toxicology, 15 (1). pp. 1013-1020. ISSN 09739122

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Abstract

Background: Candidasp. is the most common opportunistic pathogen found during the development of Human immunodeficiency virus (HIV) & Acquired immune deficiency syndrome (AIDS) disease. The clinical severity of oral candidiasis and the prevalence profile of Candida species reflect immunological changes in HIV / AIDS patients. Objective: Evaluating the relationship between CD4 T lymphocyte cells counts and the number of Candida species. Methods: A cross-sectional analytical study was carried out at Dr. Soetomo, Surabaya, Indonesia. For identification of Candida species, culture was carried out on Chromagar media followed by culture with vitek 2. Results: There were 114 study subjects who were divided into three groups based on the number of CD4 T lymphocyte cells, with 158 isolates of Candidaspecies growing in culture. The highest number of Candida species was Candida albicans with a total of 107 isolates (67.7%). Candida non-albicans were 51 isolates (32.3%). Statistical test results showed a significant correlation between the number of CD4 T lymphocyte cells and the number of Candida species (p <0.001). Conclusion: The decrease in CD4 lymphocyte cell counts is influenced by various types of Candidasp. in oral candidiasis patients.

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