Pipit Sri Estuning Rahayu (2019) Perbedaan Jumlah Sel GLIA (Astrosit, Oligodendrosit, Dan Mikroglia) Di Cerebrum Dan Cerebellum Rattus Norvegicus Baru Lahir Yang Dipapar Musik Mozart, Pop Dan Religi Selama Kebuntingan. Thesis thesis, Universitas Airlangga.

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Abstract

Background: Glial cells make up half of the brain volume, control synapses formation, and facilitate neuronal activity. Music stimulation is an important component of prenatal fetal development. Pop and religious music are both easy to listen and accepted by the Indonesian people. Music that frequently heard may affect certain parts of the brain. Objective: To analyze the effect of Mozart, pop, and religious music exposure during pregnancy on the number of glial cells (astrocyt, oligodendrocyt, microglial) in the cerebrum and cerebellum offspring Rattus norvegicus. Methods: This study uses Rattus norvegicus as a test animal. Subjects were divided into four groups treatment namely Mozart, pop, religious, and without music exposure, with 60 minutes duration, 65dB intensity, initiated on the 10th day of pregnancy for 9 days in a soundproof chamber with the distance between speaker and cage 25cm. On the 19th day, 3 brain offsprings were chosen to be preparations were made, glial cells were counted using hematoxylin-eosin staining in 5 fields of view and 400 magnification strength. Results: Different cerebrum glial cells (astrocyte, oligodendrocyte, microglial) number were observed between groups of the newly born Rattus norvegicus. Mozart music group (astrocyte 8,00±2,94; oligodendrocyte 10,43±2,63; microglial 1l,14±1,67) was the highest compared to pop, religious, and without music exposure groups. The number of cerebellum glial cells of Rattus norvegicus newborn of Mozart music group (astrocyte J2,00±1,73; oligodendrocyte 13,14±1,77; microglial 11,00±1,15) was the highest compared to pop, religious, and without music exposure. There were significant differences of glial cells (astrocyte, oligodendrocyte, microglial) number in the cerebrum and cerebellum between Mozart group compared with pop and religious music groups with p value <0,005. Conclussion: The number of glial cells (astrocyte, oligodendrocyte, microgilal) in the cerebrum and cerebellum offspring Rattus norvegicus was in the Mozart group higher than pop, religious, and without music exposure groups.

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