Niswatun Chasanah and Achmad Bashori and Agung Krismariono (2018) EKSPRESI TGFβ1 SETELAH PEMBERIAN EKSTRAK GEL ALOE VERA PADA SOKET PENCABUTAN GIGI TIKUS WISTAR. Jurnal Biosains Pascasarjana., 20 (1). ISSN 1412-1433

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Abstract

Tooth extraction is a minor surgical procedure and the healing process takes a long time to be able to do rehabilitative treatments, namely denture treatment. Aloe vera is known as a healing plant to treat wounds and burns. Aloe vera components play a role in stimulating cytokine production. TGFβ1 is a multifunctional cytokine due to its extensive activities including regulation of synthesis and degradation of ECM components which are important for wound healing. To prove the increase in TGFβ1 expression after administration of Aloe vera gel extract with a concentration of 45%, 60%, 90% in the wistar rat tooth extraction socket. The sample population was 28 wistar rats with inclusion conditions and divided into 4 groups. Extraction method by freeze drying (lyophilization). One control group (P1) and three treatment groups with 45% (P2) Aloevera gel extract concentration, 60% concentration (P3), 90% concentration (P4). Extraction of the right lateral incisor was then applied to Aloevera gel extract into the extraction socket and carried out by suturing. Termination is done on the 7th day after tooth extraction. Preparation of reparations through Immunohistochemical staining (IHC). Hypothesis testing with Kruskal Wallis test. there was a significant increase in each treatment group (p≤0.05) except in group P2 against P4 had no significant difference. There was an increase in the expression of TGFβ1 after the administration of Aloe vera gel extract concentration of 45%,60%,90% in wistar rat tooth extraction socket.

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