Ssekalembe Geofrey (2020) Factors Influencing Tuberculosis Treatment Outcomes In Hiv Positive And Hiv Negative Patients In Surabaya, Indonesia. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Tuberculosis (TB) is still a global public health threat and main causes of death in patients with HIV infection. The risk of developing TB is between 20 and 37 times greater in people living with HIV than among those without HIV. Surabaya city ranks with the highest number of TB and HIV-TB patients in East Java. TB treatment success rates in Indonesia among the new and relapse cases in 2017 was at 85%, among previously treated cases in 2017 was at 73%, among HIV-positive TB cases registered in 2017 was at 69% far below the target of 90%. The aim of this study is to analyze the factors that influence TB treatment outcomes among HIV positive and HIV negative patients in Surabaya, Indonesia. A retrospective cohort study with HIV as the exposure of 158 TB patients aged 15 years and above that started and completed TB treatment in Surabaya in 2017 and 2018. Chi square and Mantel-Haenszel tests were used to determine the relationship and associations between TB treatment outcomes and independent variables. Relative risk difference to determine the effect of cofounding and then a multivariate binary logistic regression. Study findings showed there is a more likelihood to have a treatment success in HIV-TB patients (88.6%) than in the TB patients (82.3%). More patients had a treatment success from 6 months to 8 months than before 6 months and after 8 months. HIV does not significantly influence TB treatment outcomes in HIV-TB and non-HIV TB patients. There is no cofounding effect of the independent variables with HIV and TB treatment outcome. Age group, history of diabetes and patient category have a significant relationship to TB treatment outcomes.

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