Iwan Sahrial Hamid, - and Eduardus Bimo Aksono Herupradoto, - and Sukmanadi, - and Muhammad Thohawi Elziyad Purnama, - (2018) Antiangiogenesis activity test of tin leaf (Ficus carica L.) on the number of blood vessels and VEGF expression of chorioallantoic membrane of embryonated chicken eggs. Jurnal European Journal of Oncology Pharmac, 1 (4). pp. 1-5. ISSN 2032-7072

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Abstract

This research has been conducted on the antiangiogenesis activity test of the tin leaf (Ficus carica L.) on the number of blood vesselsand vascular endothelial growth factor (VEGF) expression of chorioallantoic membrane (CAM) of embryonated chicken eggs. Thegeneral objective of this study is the use of natural products from the F. carica L. as chemopreventive in cancer through themechanism of inhibition of angiogenesis. Inhibition of angiogenesis, supply of nutrients and oxygen to cancer cells will also beinhibited, so that indirectly cancer cells will be stunted. This study used 25 embryonated chicken eggs that divided into 5 treatmentsand each treatment has 5 repetitions. This treatment includes placebo negative controls, celecoxib-positive controls, and 3 treatmentgroups were given a water extract of F. carica L. which was divided into several doses of 75, 90, and 110 mg. The result found asignificant difference (P<.05) in the macroscopic observation of the number of blood vessels in the CAM loaded with the paper dish.Observation of VEGF expression in vascular endothelial cells in the CAM also had a significant difference (P<.05). The optimal doseof water extract of F. carica L. of 90 mg has been able to inhibit the formation of new blood vessels by 65.51% and reduce VEGFexpression by 45% in the chorioallantoic membrane. Thus, it can be concluded that the administration of water extract of F. carica L.can inhibit the formation of new blood vessels and inhibit VEGF expression Keywords: angiogenesis, chorioallantoic membrane, vascular endothelial growth factor expression

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