Leptin serum and disease activity in spondyloarthritis Repository

Leptin serum and disease activity in spondyloarthritis

Yuliasih and Luluch Mulyani (2020) Leptin serum and disease activity in spondyloarthritis. EurAsian Journal of BioSciences, 14 (1). pp. 1881-1886. ISSN 13079867

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Official URL: http://www.ejobios.org/article/leptin-serum-and-di...

Abstract

Background: Spondyloarthritis (SpA) is an active chronic inflammatory disease involving pro-inflammatory cytokines; one of which is leptin. This study aimed to determine correlation between leptin serum level and disease activity in SpA patients. Method: A cross-sectional study involving patients diagnosed with SpA was conducted according to the 2009 ASAS criteria. Leptin serum level is measured by using ELISA whilst disease activity in SpA by ASDAS-CRP. The correlation was analyzed using Spearman correlation test. Results: Fifty subjects with SpA aged 54.3±9.32 years old showed mean body mass index of 23.63±3.05 kg/m2, CRP level of 0.76±0.91 mg/dL, ESR of 40.88±16.92 mm/hour, Schober test of 12.97±1.18 cm, and chest expansion test of 1.39±0.67 cm. Median leptin level and ASDAS-CRP score were 9.6 (0.92-51.57) ng/dL and 2.2 (1.3-3.86), respectively. No correlation was found between leptin level and disease activity (p = 0.174). Conclusion: Leptin serum level cannot be used as a modality to assess disease activity in SpA.

Item Type:

Article

Uncontrolled Keywords:

leptin, spondyloarthritis, ASDAS, disease activity, adipokines

Subjects:

R Medicine > R Medicine (General)
R Medicine > RC Internal medicine

Divisions:

01. Fakultas Kedokteran > Ilmu Penyakit Dalam

Creators: