Narendra Lintang Yudhisthira (2020) Renal Histopathology After Cukrik (Mixture Of Ethanol And Methanol) Consumption In Wistar Rat. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : Cukrik mainly contain ethanol, which are known to be addictive and if consumed excessively may damage the body. Regarding the price of legal alcoholic drinks, which are too expensive for the middle to the lower class, most of them add ethanol alcohol with other substances that are relatively cheaper to increase drunkenness. One of these substances is often encountered are methanol (CH3OH) due to relatively low price. Cukrik is one of illegal drink in this country, mostly cukrik contain mixed of ethanol and methanol. Misuse of cukrik can lead to intoxication and may lead to death. Several studies have shown its effect on kidney damage. Objectives : Analyzing the effect of cukrik on the histopathological damage of male Wistar rat kidney. Method : This was experimental laboratories using a post-test only control group design. A total of 28 rats (200-250 gram) that fit the criteria were divided into four groups, C, G1, G2, and G3, with each group consisting of 7 rats. Group control (C) was given 4 mL of distilled water; groups G1, G2, and G3 were given 1ml, 2 ml, and 4 ml cukrik in orally for 14 days. The composition of cukrik consists of 20% ethanol and 4% methanol. Examination of histopathological features was carried out by identifying glomerular cells, tubular cells, and interstitial cells with HE stainning. All samples were evaluated by assessing EGTI scoring of cross-sectional slices of rat kidney tissue under a light microscope with a magnification of 400 x. Statistical analysis used the non-parametric Mann-Whitney test and the Spearman test. Results : In this study, found in glomerular examination there were significant differences between the control group with the treatment groups G1, G2 and G3 (p <0.01). Tubular examination found that there were significant differences between the control group with treatment groups G2, and G3 (p < 0.01). Interstitial examination found that there was a difference but not significant between the control group with the treatment groups G1, G2, and G3 (p> 0.01). Conclusion : Consumption of cukrik produced glomerular and tubular damage on the histopathological image of male Wistar rats' kidneys, but there was no visible damage to the interstitials cell. With higher consumption of cukrik will make tubular and glomerular damage heavier.

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