Brahmana Askandar, - and Primandono Perbowo, - and Ardi Eko Marsanto, - (2020) Disease-free survival and overall survival of cervical cancer patients after radical hysterectomy and pelvic lymph-node dissection. EurAsian Journal of BioSciences, 14 (1). pp. 1779-1785. ISSN 1307-9867

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Abstract

Introduction: Radical Hysterectomy and Pelvic Lymph-Node Dissection (RH-PLND), with or without Neoadjuvant Chemotherapy (NAC) nor Adjuvant Therapy (AT), is still the treatment of choice in stages IB-IIB of cervical cancer due to limited access to concurrent chemoradiotherapy. This study aimed to find out the 3-year Disease-Free Survival (DFS) and Overall Survival (OS) in post-RH-PLND for cervical cancer patients. Methods: This was a restrospective descriptive observational study. Sample was divided into 4 groups [group 1: RH-PLND and group 2: RH-PLND + AT (operable group); group 3: NAC + RH-PLND + AT and group 4: NAC + RH-PLND (inoperable group)]. Results: Total of eight recurrences and six mortalities, with the highest 3-years DFS and OS in group 2 (91.7%) and 1 (100%), respectively. Group 3 had the lowest 3-years DFS and OS compared to other groups (67.4 and 65.6%, respectively). Most recurrence and mortality occured in the inoperable group (five and four patients). Conclusion: The highest DFS and OS among all groups was post RH-PLND cervical cancer patients who get adjuvant therapy group and post-RH-PLND without parametric infiltration pre-operation and positive prognosis factors group, respectively.

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